Julkaisuluettelo



Vertaisarvioidut tiedeartikkelit

  1. Melasniemi H, Paloheimo M and Valmu L (1990) Nucleotide sequence of the α-amylase-pullulanase gene from Clostridium thermohydrosulfuricum. J General Microbiol 136: 447
  2. Valmu L, Autero M, Siljander P, Patarroyo M and Gahmberg C G (1991) Phosphorylation of the ß-subunit of CD11/CD18 in­tegrins by protein kinase C correlates with leukocyte adhesion. Eur J Immunol 21: 2857
  3. Li R, Nortamo P, Valmu L, Tolvanen M, Huuskonen J, Kantor C and Gahmberg C G (1993) A peptide from ICAM-2 binds to the Leu­kocyte Integrin CD11a/CD18 and inhibits endot­helial cell adhesion. J. Biol. Chem. 268, 17513-17518.
  4. Vermot-Desroches C, Wijdenes J, Valmu L, Roy C, Pigott R, Nortamo P and Gahmberg C G (1995) A CD44 monoclonal antibody differentially regulates CD11a/CD18 binding to intercellular adhesion molecules CD54, CD102 and CD50. Eur J Immunol 25: 2460
  5. Valmu L and Gahmberg C G (1995) Treatment with okadaic acid reveals strong threonine phosphorylation of CD18 after activation of CD11/CD18 leukocyte integrins with phorbol esters or CD3 antibodies. J Immunol 155: 1175
  6. Valmu L, Hilden T J, van Willigen G and Gahmberg C G (1999) Characterization of b2 (CD18) integrin phosphorylation in phorbol ester activated T lymphocytes. Biochem J 339: 119
  7. Valmu L, Fagerholm S, Suila H and Gahmberg C G (1999) The cytoskeletal association of CD11/CD18 leukocyte integrins in phorbol ester activated cells correlates with CD18 phosphorylation. Eur J Immunol 29: 2107
  8. Kovanen P E, Junttila K, Takaluoma K, Saharinen P, Valmu L, Li W and Silvennoinen O (2000) Regulation of Jak2 tyrosine kinase by protein kinase C during macrophage differentation of IL-3-dependent myeloid progenitor cell. Blood 95: 1626
  9. Vassilieva L, Valmu L, Kääriäinen L and Merits A (2001) Site-specific protease activity of the carboxy-terminal domain of Semliki Forest Virus replicase protein nsP2. J Biol Chem 276: 30786
  10. Hilden T J, Valmu L, Kärkkäinen S and Gahmberg C G (2003) Threonine phosphorylation sites in the beta2 and beta7 leukocyte integrin polypeptides. J Immunol 170: 4170
  11. Ivanov K I, Puustinen P, Gabrenaite R, Vihinen H, Rönnstrand L, Valmu L, Kalkkinen N and Mäkinen K (2003) Phosphorylation of the Potyvirus Capsid Protein by Protein Kinase CK2 and Its relevance for Virus Infection. Plant Cell 15: 2124
  12. Pihlajamaa T, Lankinen H, Valmu L, Peränen J, Jäälinoja J, Zaucke F, Spitznagel L, Gösling S, Maurer P, Puustinen A, Ylöstalo J, Ala-Kokko L and Kilpeläinen I (2004) Characterization of recombinant amino-terminal NC4 domain of human collagen IX. Interaction with glycosaminoglycans and cartilage oligomeric matrix protein. J Biol Chem 279: 24265
  13.  Elo M A, Karjalainen H M, Sironen R K, Valmu L, Redpath N T, Browne G, Kalkkinen N, Helminen H J and Lammi M J (2004) High hydrostatic pressure inhibits the biosynthesis of eukaryotic elongation factor-2. J Cell Biochem 94: 497
  14.  Savijoki K, Suokko A, Palva A, Valmu L, Kalkkinen N and Varmanen P (2005) Proteomic investigation of Bifidobacterium longum using [35S]Methionine Labelling, Two-Dimensional Gel Electrophoresis and Mass spectrometry. FEMS Microbiology Letters 248: 207
  15. Stenman M, Ainola M, Valmu L, Bjartell A, Ma G, Stenman U-H, Sorsa T, Luukkainen R and Konttinen Y T (2005) Trypsin-2 degrades human type II collagen and is expressed and activated in mesenchymally transformed rheumatoid arthritis synovitis tissue. Am J Pathology 167: 1119
  16. Valmu L, Kalkkinen N, Husa A and Rye P D (2005) Differential susceptibility of transferrin glycoforms to chymotrypsin: a potential approach to the detection of carbohydrate deficient transferrin. Biochemistry 44: 16007
  17. Valmu L, Paju A, Lempinen M, Kemppainen E and Stenman U-H (2006)Application of proteomic technology in identifying Pancreatic Secretory Trypsin Inhibitor variants in urine of patients with pancreatitis. Clin Chem 52: 73
  18. Hallikas O K, Aaltonen J M, von Koskull H, Lindberg L A, Valmu L, Kalkkinen N, Wahlström T, Kataoka H, Andersson L, Lindholm D and Schröder J (2006) Identification of antibodies against HAI-1 and integrin α6β4 as immunohistochemical markers of human villous cytotrophoblast. J Histochem Cytochem 54: 745
  19. Joensuu J J, Kotiaho M, Teeri T H, Valmu L, Nuutila A M, Oksman-Caldentey K-M and Nikander-Teeri V (2006) Glycosylated F4 (K88) fimbrial adhesin, FaeG expressed in barley endosperm induces ETEC neutralizing antibodies in mice. Transgenic Research 15: 359
  20. Salonen J, Valmu L, Rönnholm G, Kalkkinen N and Vihinen M (2006) Proteome analysis of B cell maturation. Proteomics 6: 5152
  21. Valmu L, Alfthan H, Hotakainen K, Birken S and Stenman U-H (2006) Site-specific glycan analysis on human chorionic ganadotropin β-subunit from malignancy and pregnancy by liquid chromatography-electrospray mass spectrometry. Glycobiology 16: 1207
  22. Rouhiainen A, Tumova S, Valmu L, Kalkkinen N and Rauvala H (2007) Analysis of proinflammatory activity of highly purified eukaryotic recombinant amphoterin (HMGB1) J Leuk Biol 81: 49
  23. Hyyryläinen H-L, Pietiäinen M, Lunden T, Ekman A, Gardemeister M, Murtomäki-Repo S, Antelmann H, Hecker M, Valmu L, Sarvas M and Kontinen V P (2007) The density of negative charge in the cell wall influences two-component signal transduction in Bacillus subtilis. Microbiology 153: 2126
  24. Itkonen O, Helin J, Saarinen J, Kalkkinen N, Ivanov K I, Stenman U-H and Valmu L (2008) Mass spectrometric detection of tyrosine sulfation in human pancreatic trypsinogens, but not in tumor-associated trypsinogen. FEBS Journal 275:289
  25. Liiv I, Rebane A, Org T, Saare M, Maslovskaja J, Kisans K, Juronen E, Valmu L, Bottomley M, Kalkkinen N and Peterson P (2008) DNA-PK contributes to the phosphorylation of AIRE: importance in transcriptional activity. BBA Mol Cell Res J 1783: 74
  26. Mattson J, Valmu L, Laakkonen P, Stenman U-H and Koistinen H (2008) Structural characterization and anti-angiogenic properties of prostate specific antigen isoforms in seminal fluid. Prostate 68: 945
  27. Heiskanen A, Hirvonen T, Salo H, Impola U, Olonen A, Laitinen A, Tiitinen S, Natunen S, Aitio O, Miller-Podraza H, Wuhrer M, Deelder A, Natunen J, Lainen J, Lehenkari P, Saarinen J, Satomaa T and Valmu L (2009) Glycomics of bone marrow-derived mesenchymal stem cells can be used to evaluate their cellular differentiation stage. Glycoconj J 26: 367
  28. Koistinen H, Koistinen R, Zhang W-M, Valmu L and Stenman U-H (2009) Nexin-1 inhibits the activity of human brain trypsin. Neuroscience 160: 97
  29. Nystedt J, Anderson H, Hirvonen T, Impola U, Jaatinen T, Heiskanen A, Blomqvist M, Satomaa T, Natunen J, Saarinen J, Lehenkari P, Valmu L and Laine J (2010) Human CMP-N-acetylneuraminic acid hydroxylase (CMAH) is a Novel Stem Cell Marker Linked to Stem Cell-Specific Mechanisms. Stem Cells 28:258
  30. Suila H, Pitkänen V, Hirvonen T, Heiskanen A, Anderson H, Laitinen A, Natunen S, Miller-Podraza H, Satomaa T, Natunen J, Laitinen S, and Valmu L (2011) Are globoseries glycosphingolipids SSEA-3 and -4 markers for adult stem cells derived from human umbilical cord blood? J Mol Cell Biol 3:99
  31. Natunen S, Satomaa T, Pitkänen V, Salo H, Mikkola M, Natunen J, Otonkoski T and Valmu L (2011) The binding specificity of the marker antibodies Tra-1-60 and Tra-1-81 reveals a novel pluripotency associated type 1lactosamine epitope. Glycobiology 9:1125
  32. Hirvonen T., Suila H., Kotovuori A., Ritamo I., Heiskanen A., Sistonen P., Anderson H., Satomaa T., Saarinen J., Tiitinen S., Räbinä J., Laitinen S., Natunen S., and Valmu L (2011) The i blood group antigen as a cord blood derived mesenchymal stem cell marker. Stem Cells Dev 21: 455

  33. Kolmeder C A, de Been M, Nikkilä J, Ritamo I, Mättö J, Valmu L, Palva A, Salonen A and de Vos W M (2012) Comparative metaproteomics and Diversity Analysis of Human Intestinal Microbiota Testifies for Temporal Stability of Core Functions. Plos ONE 7: e29913

  34. Karhemo P-R, Ravela S, Laakso M, Ritamo I, Tatti O, Mäkinen S, Goodison S, Stenman U-H, Hölttä E J, Hautaniemi S, Valmu L, Lehti K I, Laakkonen P M (2012) An optimized isolation of biotinylated cell surface proteins reveals novel players in cancer metastasis J Proteomics 77:87

  35. Pietilä M, Palomäki S, Lehtonen S, Ritamo I, Valmu L, Nystedt J, Laitinen S, Leskelä H-V, Sormunen R, Pesälä J, Nordström K, Vepsäläinen A and Lehenkari P (2012) Mitochondrial function and energy metabolism in umbilical cord blood- and bone marrow-derived mesenchymal stem cells. Stem Cells Dev 4:575

  36. Mikkola M, Toivonen S, Tamminen K, Alftan K, Tuuri T, Valmu L, Partanen J, Satomaa T, Natunen J, Saarinen J ja Otonkoski T (2012) Lectin from Erythrina cristagalli supports undifferentiated growth and differentiation of human pluripotent stem cells. Stem Cells Dev 5:707

  37. Nystedt J, Anderson H, Tikkanen J, Pietilä M, Hirvonen T, Heiskanen A, Satomaa T, Natunen S, Lehtonen S, Hakkarainen T, Takalo R, Laitinen S, Valmu L and Lehenkari P (2013) Cell surface structures influence lung clearance rate of systemically infused mesenchymal stromal cells. Stem Cells 2:317

  38. Kerkelä E, Hakkarainen T, Mäkelä T, Kilpinen L, Lehtonen S, Ritamo I, Pernu R, Pietilä M, Takalo R, Nikkilä J, Tikkanen J, 3, Juvonen T, Laitinen S, Valmu L, Lehenkari P and Nystedt J (2013) Transient Proteolytic Modification of Mesenchymal Stromal Cells Decreases Lung Entrapment in vivo. Stem Cell Transl Med 7:510

  39. Natunen S, Lampinen M, Suila H, Räbinä J, Laitinen S, Reutter W and Valmu L (2013) Metabolic glycoengineering of mesenchymal stem cells with N-propanoylmannosamine. Glycobiology 8:1004

  40. Ivanov K I, Agalarov Y, Valmu L, Samuilova O, Liebl J, Houhou N, Maby-El Hajjami H, Norrmen C, Jaquet M, Miura N, Zangger N, Ylä-Herttuala S, Delorenzui M and Petrova T V Konstantin I. (2013) Phosphorylation Regulates FOXC2-Mediated Transcription in Lymphatic Endothelial Cells. Mol Cell Biol 19:3749

  41. Hirvonen T, Suila H, Tiitinen S, Natunen S, Laukkanen M-L, Kotovuori A, Reinman M, Satomaa T, Alftan K, Laitinen S, Takkinen K, Räbinä J and Valmu L (2013) Production of a recombinant antibody specific for i blood group antigen, a mesenchymal stem cell marker. Biores Open Access 5:336

  42. Ritamo I, Räbinä J, Natunen S and Valmu L (2013) Nanoscale reversed-phase liquid chromatography-mass spectrometry of permethylated N-glycans. Anal Bioanal Chem 8:2469

  43. Kilpinen L, Impola U, Sankkila L, Ritamo I, Aatonen M, Kilpinen S, Tuimala J, Valmu L, Levijoki J, Finckenberg P, Siljander P, Kankuri E, Mervaala E and Laitinen S (2013) Extracellular membrane vesicles from umbilical cord blood-derived MSC protect against ischemic acute kidney injury, a feature that is lost after inflammatory conditioning. J Extracell Vesicles doi: 10.3402/jev.v2i0.21927

  44. Peltoniemi H, Natunen S, Ritamo I, Valmu L and Räbinä J (2013) Novel data analysis tool for semiquantitative LC-MS-MS2 profiling of N-glycans. J Glycoconj J 2:159

  45. Leymarie N, Griffin PJ, Jonscher K, Kolarich D, Orlando R, McComb M, Zaia J, Aguilan J, Alley WR, Altmann F, Ball LE, Basumallick L, Bazemore-Walker CR, Behnken H, Blank MA, Brown KJ, Bunz SC, Cairo CW, Cipollo JF, Daneshfar R, Desaire H, Drake RR, Go EP, Goldman R, Gruber C, Halim A, Hathout Y, Hensbergen PJ, Horn DM, Hurum D, Jabs W, Larson G, Ly M, Mann BF, Marx K, Mechref Y, Meyer B, Möginger U, Neusüβ C, Nilsson J, Novotny MV, Nyalwidhe JO, Packer NH, Pompach P, Reiz B, Resemann A, Rohrer JS, Ruthenbeck A, Sanda M, Schulz JM, Schweiger-Hufnagel U, Sihlbom C, Song E, Staples GO, Suckau D, Tang H, Thaysen-Andersen M, Viner RI, An Y, Valmu L, Wada Y, Watson M, Windwarder M, Whittal R, Wuhrer M, Zhu Y and Zou C (2013) Interlaboratory study on differential analysis of protein glycosylation by mass spectrometry: the ABRF glycoprotein research multi-institutional study 2012. Mol Cell Proteomics 10:2935

  46. Suila H, Hirvonen T, Kotovuori A, Ritamo I, Kerkelä E, AndersonH, Natunen S, Tuimala J, Laitinen S, Nystedt J, Räbinä J and Valmu L (2014) Human umbilical cord blood derived mesenchymal stem cells display a novel interaction between P-selectin and galectin-1. Scand J Immunol 80:12

  47. Suila H, Hirvonen T, Natunen S, Tuimala J, Laitinen S, Anderson H, Nystedt J, Räbinä J and Valmu L (2014) Extracellular O-linked N-Acetylglucosamine is enriched in human umbilical cord blood derived mesenchymal stem cells. Biores Open Access 2:39

  48. Ritamo I, Cloutier M, Valmu L, Néron S, Räbinä J. (2014) Comparison of the glycosylation of in vitro generated polyclonal human IgG and therapeutic immunoglobulins. Mol Immunol 2:255

  49. Ravela S, Valmu L, Domanskyy M, Koistinen H, Kylänpää L, Lindström O, Stenman J, Hämäläinen E, Stenman UH and Itkonen O (2018) An immunocapture-LC-MS-based assay for serum SPINK1 allows simultaneous quantification and detection of SPINK1 variants. Anal Bioanal Chem 6:1679

  50. Luukkonen J, Hilli M, Nakamura M, Ritamo I, Valmu L, Kauppinen K, Tuukkanen J, Lehenkari P. (2019) Osteoclasts secrete osteopontin into resortion lacunae during bone resortion. Histochem Cell Biol 6: 475


Katsaukset

  1. Gahmberg, C. G., Nortamo, P., Kantor, C., Autero, M., Koto­vuori, P., Hemiö, L., Salcedo, R. & Patarroyo, M. (1990) The pivotal role of the Leu-CAM and ICAM molecules in human leuko­cyte adhesion. In: Proceedings of the XIII Sigrid Jusélius Symposium "Cell-matrix and pericellular proteolysis", Cell Diff. Devel., 32, pp. 239-246.
  2. Gahmberg, C. G., Nortamo, P., Kotovuori, P., Tontti, E., Li, R., Valmu, L., Autero, M. and Tolvanen, M. (1992) Activation and binding of leukocyte integrins to their ligands. In: Leuko­cyte Adhesion, Basic and Clinical Aspects. Gahmberg, C. G., Mendrup-Poulsen, T., Wogensen Bach, L. and Hökfelt, B. (eds.) Elsevier Science Publishers B.V. Amsterdam. Excerpta Medica, International Congress Series 1010, pp. 205-219.
  3. Gahmberg, C. G., Nortamo, P., Li, R. and Valmu, L. (1992) Leu­kocyte cell adhesion proteins: From molecular dissection to clinical applications. Ann. Med. 24, 329-335.
  4. Gahmberg, C. G., Tolvanen, M., Nortamo, P., Li, R., Kantor, C., Xie, J., Kotovuori, P., Puustinen, A., Valmu, L., Ylänne, J. and Tontti, E. (1994) The intercellular adhesion molecules (ICAMs). In: Adhesion receptors as therapeutic targets. M. A. Horton (ed.) CRC Press, Inc., Boca Raton, FL, USA. pp. 37-59.
  5. Gahmberg, C. G., Valmu, L., Fagerholm, S., Kotovuori, P., Ihanus, E., Tian, L. & Pessa-Morikawa, T. (1997) Leukocyte integrins and inflammation. Cell. Mol. Life Sci. 54, 549-555.
  6. Gahmberg, C. G., Valmu, L., Tian, L., Kotovuori, P., Fagerholm, S., Kotovuori, A., Kantor, C. and Hilden, T. (1999) Leukocyte adhesion - a fundamental process in leukocyte physiology. Braz. J. Med. Biol. Res. 32, 511-517.
  7. Gahmberg, C. G., Valmu, L., Kotovuori, A., Kotovuori, P., Hilden, T. J., Fagerholm, S., Kantor, C., Nurminen, T., Ihanus, E. and Tian, L. (1999) Leukocyte adhesion - an integrated molecular process at the leukocyte plasma membrane. Biosci. Reports 19, 273-281.
  8. Stenman, U-H., Tiitinen, A., Alfthan, H. and Valmu, L. (2006) The classification, functions, and clinical use of different isoforms of hCG. Hum Reprod Update 12, 769-84
  9. Valmu, L., Ravela, S. and Stenman, U-H. (2010) Proteomic analysis of pancreatic secretory Trypsin inhibitor/Tumor-associated Trypsin Inhibitor from urine of patients with Pancreatitis or Prostate Cancer. Methods Mol Biol. 641, 347-57.
  10. Peltoniemi, H., Ritamo, I., Räbinä, J., Valmu, L. (2011) Automated N-glycan Composition Analysis with LC-MS/MSMS. In: Glyco-Bioinformatics, Bits'n'bytes of Sugars. Hicks, M.G. and Kettner C (eds.) Logos Verlag Berlin, Potsdam, Germany, pp. 37-47.

Patentit

  1. Tiitinen S, Hirvonen T, Valmu L, Satomaa T, Heiskanen A and Natunen J (2007) Uusia solupopulaatioita/Nya cell populationer
  2. Laukkanen M-L, Takkinen K, Natunen J, Satomaa T, Parkkinen J, Valmu L, Tiitinen S, Natunen S (2007) Human Monoclonal Antibodies Directed To Sialyl Lewis C, Sialyl TN and N-Glycolylneuraminic Acid Epitopes and a Method of Analysis of Stem Cells Comprising said Epitopes
  3. Laine J, Satomaa T, Natunen J, Heiskanen A, Blomqvist M, Olonen A, Saarinen J, Tiitinen S, Impola U, Mikkola M, Valmu L and Tiittanen M (2007) Novel Methods and Reagents Directed to Production of Cells
  4. Laine J, Satomaa T, Natunen J, Heiskanen A, Blomqvist M, Olonen A, Saarinen J, Tiitinen S, Impola U, Aitio O, Valmu L, Anderson H, Pitkänen V, Partanen J and Jaatinen T (2007) Novel Carbohydrate from Human Cells and Methods for Analysis and Modification Thereof
  5. Laine J, Satomaa T, Natunen J, Heiskanen A, Blomqvist M, Olonen A, Saarinen J, Tiitinen S, Impola U, Mikkola M, Salo H, Aitio O, Valmu L, Natunen S, Anderson H, Pitkänen V, Partanen J, Jaatinen T, Tiittanen M and Hirvonen T (2007) Novel Carbohydrate Profile Compositions from Human Cells and Methods for Analysis and Modification Thereof
  6. Natunen S, Satomaa T, Natunen J, Valmu L and Pitkänen V (2007) Novel Acidic Glycan Markers of Human Cells
  7. Laine J, Satomaa T, Natunen J, Heiskanen A, Blomqvist M, Olonen A, Saarinen J, Tiitinen S, Impola U, Aitio O, Valmu L, Natunen S and Salo H (2007) Novel Specific Cell Binders
  8. Nystedt J, Anderson H, Valmu L, Natunen J and Satomaa T (2008) Enzymatical Modification of Cell Glycosylation Using Serum Albumin and Divalent Cations
  9. Hirvonen T, Kotovuori A, Pitkänen V, Natunen S, Nystedt J, Tiitinen S, Valmu L and Natunen J (2008) Method of Evaluating the Integrity of the Plasma Membrane of Cells by Detecting Glycans Found Only Intracellularly
  10. Valmu L, Ritamo I, Peltoniemi H and Räbinä J (2009) Cell Surface Profile
  11. Satomaa T, Natunen S, Valmu L and Natunen J (2009) Antibodies Directed to TRA Antigers, and Methods of Production, Screening and Analysis of said Antibodies, as well as Methods of Analysis of Stem Cells and Cancer Cell
  12. Kotovuori A, Natunen S and Valmu L (2009) Method of Distinguishing Undifferentiated Mesenchymal Stem Cells and Differentiated Mesenchymal Stem Cells from Each Other by Using an Antibody Against the Blood Group I Antigen
  13. Nystedt J, Hakkarainen T, Lehenkari P, Kerkelä E and Valmu L (2010) Use of a Proteolytic Enzyme for the Modification of the Cell Surface of a Stem Cell
  14. Partanen J, Natunen J, Kotovuori A, Natunen S and Valmu L (2010) Method for Isolating Cells and a Cell Population Thereof
  15. Kotovuori A, Natunen S and Valmu L (2010) Method for isolating CD34+ Hematopoietic Stem Cells, Natural Killer Cells and Regulatory T Lymphocytes from a Sample of Human Umbilical Cord Blood by Using an Anti-GD3 Antibody, as well as Compositions Thereof
  16. Lähteenmäki K, Mättö J, Valmu L, Wacklin P, Ritamo I and Partanen J (2010) Induced Proteins
  17. Rannisto J, Flook K, Valmu L, Saarainen V, Ravela S and Finell J (2015) Extraction Column
  18. Rannisto J, Ravela S, Flook K, Finell J, Valmu L, Borislav M, Saarainen V and Pohl C (2015) Extraction Column
  19. Saarainen V, Rannisto J, Ravela S, Valmu L, Finell J and Flook K (2016) Extraction Column Array
  20. Koskinen M, Valmu L, Rannisto J, Flook K, Grist R and Rantakari A (2016) Mass Spectrometric Methods and Kits to Identify a Microorganism